• Using our infection assays we also explored whether low pH

  2023-05-29

  

  Using our infection assays, we also explored whether low-pH compartments were required for the entry of ZIKVs in mammalian cells. Lysosomotropic agents such as ammonium chloride, chloroquine and Bafilomycin A1, strongly inhibited the ability of ZIKVs to enter mammalian cells. Our results are in agre

• br Acknowledgement This work was funded by NIH

  2023-05-29

  

  Acknowledgement This work was funded by NIH/NINDS grant number NS080967 to C. Waites. Introduction Macro-autophagy also called autophagy is a conserved pathway for the lysosomal degradation and recycling of intracellular materials. It is instrumental for the homeostasis of cells and tissues a

• It is well known that neurosteroids

  2023-05-29

  

  It is well-known that neurosteroids such as testosterone and their metabolites endogenously modulate neural excitability in animals and humans. Testosterone has protective effects against seizures induced by KA and PTZ (Frye et al., 2001b; Reddy, 2004b). Estrogens, on the other hand, have proconvuls

• br Leptin Adiponectin a permissive imbalance

  2023-05-29

  

  Leptin/Adiponectin: a permissive imbalance Leptin, a satiety hormone, is encoded by the obesity (ob) gene. It essentially functions as an energy sensor which is involved in the regulation of body weight by sending signals to the AS 101 to reduce appetite (Woods and D'Alessio, 2008). Obesity resu

• Spectroscopic techniques are powerful biophysical tools used

  2023-05-26

  

  Spectroscopic techniques are powerful biophysical tools used in the study of biomolecular structures, including those of proteins. UV–Vis SR 1555 hydrochloride sale spectroscopy makes use of absorption property of the protein peptide backbone at around 218 nm, and aromatic amino acid residues prima

• Fenretinide Our studies suggest that AdipoR and

  2023-05-26

  

  Our studies suggest that AdipoR1 and AdipoR2 genes are expressed in multiple tissues in the chicken wherein both receptors are likely to mediate the physiological effects of adiponectin. We determined the relative expression of AdipoR1 and AdipoR2 mRNA in various tissues and found that skeletal musc

• Adenosine is an endogenous nucleoside that plays pivotal rol

  2023-05-26

  

  Adenosine is an endogenous nucleoside that plays pivotal roles in different physiological and pathophysiological processes by triggering specific cell-surface receptors both in the vasopressin receptor and in the periphery. The adenosine receptors (ARs) are four different subtypes of G protein-coupl

• br GMF Remodels Actin Networks at

  2023-05-26

  

  GMF Remodels Actin Networks at the Leading Edge How are the conserved activities of GMF used in vivo to regulate branched opioid receptor antagonist networks (e.g., at sites of endocytosis and at the leading edge) (Figure 2A,B)? In animal cells, the regulatory effects of GMF on actin networks app

• Another significant group of reductase inhibitors is the

  2023-05-26

  

  Another significant group of 5α-reductase inhibitors is the steroidal 3-carboxylic autophagy pathway derivatives (relevant examples in Fig. 5), which were designed to mimic the putative enzyme-bound enolate intermediate. This was achieved by introducing sp2-hybridized centers at C3 and C4 and an an

• Based on these findings the time point for

  2023-05-26

  

  Based on these findings, the time point for manipulating autophagy may also determine its role, whereby autophagy induction performed before ischemia could play a protective role but have an opposite effect once ischemia/reperfusion has occurred. This hypothesis is further supported by the protectiv

• br Introduction Human esophageal carcinoma is one of the mos

  2023-05-26

  

  Introduction Human esophageal carcinoma is one of the most frequently diagnosed cancers, ranked as the eighth leading causes of cancer-related mortality worldwide. Esophagus squamous cell carcinoma (ESCC) is the most common histological type of esophageal carcinomas, especially with a higher inci

• Maintaining the normal vaginal fluid acidity is important fo

  2023-05-26

  

  Maintaining the normal vaginal fluid acidity is important for vaginal functions (Wagner and Levin 1984). Estrogen has been shown essential in maintaining the acidity of vaginal fluid, in which its deficiency could cause vaginal fluid pH to increase (Gorodeski et al. 2005). After menopause, low estro

• Oxybutynin IGF is an anabolic growth factor that

  2023-05-26

  

  IGF1 is an anabolic growth factor that induces hypertrophy and blocks atrophy in skeletal muscle by activating the PI3K/AKT/mTOR pathway (Egerman and Glass, 2014). In addition to its anabolic and anti-catabolic effects, IGF1 stimulates fatty Oxybutynin (FA) uptake and glucose metabolism (Clemmons,

• br Acknowledgements br Introduction Double stranded DNA

  2023-05-26

  

  Acknowledgements Introduction Double-stranded DNA breaks (DSBs) are among the most deleterious DNA lesions that threaten genomic integrity. DSBs are generated not only by exogenous DNA-damaging agents but also by normal cellular processes such as V(D)J recombination, meiosis, and DNA replicati

• br Conclusion We have identified potential inhibitors of

  2023-05-26

  

  Conclusion We have identified potential inhibitors of C. albicans fungus specific nuclear target outer kinetochore Dam1 complex subunit Ask1, virtually screened through the PubChem compounds database (NCBI, USA) by utilizing state-of-art in silico methods in a pipeline. The 3D protein structure o

14259 records 297/951 page Previous Next First page 上5页 296297298299300 下5页 Last page