• Because R gene is positively regulated by T and

  2022-12-09

  

  Because 5α-R2 gene is positively regulated by T and in the prostate gland (Torres et al., 2003), and our BPA-treated rats showed decreased circulating T and probably intraprostatic androgen levels, it might be responsible for the decrease of 5α-R2 expression. However, in a previous work using castra

• Hypoxia of the adipose tissue is a key step in

  2022-12-09

  

  Hypoxia of the adipose tissue is a key step in the inflammatory response linked to obesity and contributes to accelerated tumor progression in the obese population (Rosenow et al., 2013). Intermittent hypoxia exposure induces a 2.2-fold increase in the infiltration of tumor-associated macrophages an

• Introduction Antimicrobial resistance is a growing health

  2022-12-09

  

  Introduction Antimicrobial resistance is a growing health threat worldwide that has been associated with incorrect prescription and overuse of Oseltamivir acid [1]. Considering that physicians play a central role in antibiotic usage, a better understanding of their prescribing behaviours and their

• Although several ARIs have reached various phases of

  2022-12-09

  

  Although several ARIs have reached various phases of clinical experimentation however most of them have been withdrawn either due to an insufficient bioavailability, their poor efficacy or adverse side effects. Currently Epalrestat is in clinical use for the treatment of diabetic neuropathy. The sid

• These mutations induce the gene auto

  2022-12-09

  

  These mutations induce the gene auto-activation in 10–40% of adenocarcinomas, triggering the EGFR-signaling pathway in the absence of ligand. That leads to an uncontrolled acceleration of cell proliferation, survival and anti-apoptotic signals (Couraud et al., 2012). The frequency of these mutations

• Our previous work fails to show any

  2022-12-08

  

  Our previous work fails to show any maternal effect with blockade of 5-HT2A receptor, as acute and repeated treatment of MDL100907 does not alter maternal behavior at the behaviorally active doses (Chen et al., 2014). In the present study, MDL100907 pretreatment attenuated the maternal disruptive ef

• Our previous work fails to show any

  2022-12-08

  

  Our previous work fails to show any maternal effect with blockade of 5-HT2A receptor, as acute and repeated treatment of MDL100907 does not alter maternal behavior at the behaviorally active doses (Chen et al., 2014). In the present study, MDL100907 pretreatment attenuated the maternal disruptive ef

• br Conflicts of interest br Acknowledgments br Significance

  2022-12-07

  

  Conflicts of interest Acknowledgments Significance Introduction Androgen receptor (AR) plays a paramount role in the onset and progression of prostate cancer (PC) (Burnstein, 2005, Lonergan and Tindall, 2011, Watson et al., 2015). This very facet underlies androgen deprivation therapy (A

• Previously we reported that EL Kras mice fed diets rich

  2022-12-07

  

  Previously, we reported that EL-Kras mice-fed diets rich in omega-6 FAs demonstrated increased pancreatic mast cell infiltration [16]. Significantly, increased infiltration of mast cells into the tumor microenvironment correlates with a poor prognosis [15]. Soucek et al.[25] demonstrated that mast c

• Gene regulation of MMPs is influenced by

  2022-12-05

  

  Gene regulation of MMPs is influenced by the transcription factor activating factor-1 (AP-1). AP-1 complexes are heterodimers of proteins of the two proto-oncogene families (jun and fos) and have LEE011 in the promoter region of MMPs, as well as in genes mediating inflammatory responses. The transc

• To further evaluate the influence of antibiotics on allergy

  2022-12-05

  

  To further evaluate the influence of EW-7197 on allergy, Russel et al. initiated vancomycin treatment during pregnancy in mice and continued it for several weeks after birth. This resulted in exaggerated OVA-induced allergic inflammation, characterized by higher numbers of lung eosinophils, elevated

• A unique finding in this study is that LO

  2022-12-02

  

  A unique finding in this study is that 12/15-LO influences CREB phosphorylation in the murine brain. While previous reports have found that knockout of 5-lipoxygenase, a related enzyme that also uses arachidonic E3330 for substrate, can regulate CREB phosphoryation in the context of Alzheimer's dis

• AdipoR and AdipoR have been

  2022-12-02

  

  AdipoR1 and AdipoR2 have been reported to be present in almost all type of tissues and low Brefeldin A levels have been observed in white adipose tissue (Inukai et al., 2005). These receptors have been observed to become deregulated with the onset of obesity, resulting in a reduced level of APN exp

• In recent years there have been further significant

  2022-12-02

  

  In recent years, there have been further significant developments that enhance an understanding of the role of adenosine in nociception. Thus, novel methods of recruiting adenosine A1Rs have been developed, and the role of adenosine A2A- and A3Rs in nociception has been further elaborated. Furtherm

• Sperm total motility and hyperactivated motility are mediate

  2022-12-02

  

  Sperm total motility and hyperactivated motility are mediated by PLD-dependent SB 366791 australia polymerization [20]. Reduction of PIP2 synthesis inhibited actin polymerization and motility, and increasing PIP2 synthesis enhanced these activities. Furthermore, sperm demonstrating low motility con

14259 records 340/951 page Previous Next First page 上5页 336337338339340 下5页 Last page