• ABT-737: Mechanistic and Translational Implications for B...

  2025-09-22

  Explore the multifaceted applications of ABT-737, a potent BH3 mimetic and small molecule BCL-2 protein inhibitor, with emphasis on its mechanistic insights and translational significance in apoptosis induction across cancer models, including lymphoma, multiple myeloma, SCLC, and AML.

• ARCA Cy5 EGFP mRNA (5-moUTP): Illuminating mRNA Delivery ...

  2025-09-19

  Explore the unique advantages of ARCA Cy5 EGFP mRNA (5-moUTP) as a fluorescently labeled mRNA for delivery analysis and translation efficiency assays. This article delves into the roles of chemical modifications, advanced capping, and dual-fluorescence labeling in dissecting mRNA delivery and localization in mammalian cells.

• Optimizing Polyadenylation of RNA Transcripts with HyperS...

  2025-09-18

  Explore how the HyperScribe™ Poly (A) Tailing Kit streamlines the polyadenylation of RNA transcripts for enhanced mRNA stability and translation efficiency in advanced molecular biology applications.

• Exposure to B a P is an epidemiologically proven cause

  2025-03-03

  

  Exposure to B[a]P is an epidemiologically proven cause of lung cancer (Hecht, 2003; Rojas et al., 2004; Alexandrov et al., 2010), and the formation of B[a]PDE-N2-dG adducts is considered to be the critical event in lung tumorigenesis by B[a]P. On the other hand, there is evidence suggesting that the

• Kifunensine To verify whether circulating APN

  2025-03-03

  

  To verify whether circulating APN could protect cognitive function during aging, we detected the alterations in circulating adipoenctin levels in aging rats. Our results suggested that circulating APN levels reduced with age. Kawasumi et al’s study results are consistent with ours. They concluded th

• br Materials and methods br Results Bilateral microinjection

  2025-03-03

  

  Materials and methods Results Bilateral microinjections (n = 6) of 10 mM ACh (300–500 pmol) and 5 mM physostigmine (150–250 pmol) at the two selected caudal NTS sites caused within 1 min significant increases in respiratory frequency (from 54.5 ± 1.7 to 70.9 ± 4.1 breaths/min; +30.8 ± 7.0%; P 

• The structures of these compounds were

  2025-03-03

  

  The structures of these compounds were confirmed from their spectral and micro analytical data. Based on [M + H] 367, molecular formula of was established as CHON. The IR spectrum of showed Dopamine receptor agonist due to CO stretching at 1700 Cm & OH stretching at 3188 Cm indicating that compound

• A rational approach for the

  2025-03-03

  

  A rational approach for the design of new steroid compounds as possible competitive inhibitors of CYP17 include chemical modification at C17 of the enzyme's natural substrates, pregnenolone (1) and progesterone (2), introducing groups with moderate to strong dipole properties at C20, such as oxime a

• Hexachlorophene disinfectant br Dual role of autophagy in hu

  2025-03-03

  

  Dual role of autophagy in human diseases Emerging evidence suggests that autophagy serves as a double-edged sword in several human diseases, such as CNS diseases (Rubinsztein et al., 2015), arteriosclerosis (Schrijvers et al., 2011) and cancer (Ozpolat and Benbrook, 2015). Likewise, currently the

• In this report the natural compound deguelin potently

  2025-03-03

  

  In this report, the natural compound deguelin potently and dose-dependently suppressed Aurora B kinase activity in vitro, indicating that this compound is an effective Aurora B inhibitor. The docking study indicated that deguelin was docked into the ATP-binding pocket of Aurora B and formed hydropho

• br Synthetic lethal approaches In addition to

  2025-03-01

  

  Synthetic lethal approaches In addition to the potential utility of ATM and ATR as chemo- or radiosensitisers, recent studies suggest that such compounds may have single agent activity in certain subsets of patients through induction of synthetic lethality. Two genes are considered synthetically

• Recent progress has been made in translating animal

  2025-03-01

  

  Recent progress has been made in translating animal findings on memory performance and amnestic effects – that are largely determined by tonically active receptors in which α5 contributes to the benzodiazepine binding site. Based on the observation that deletion of this subunit led to improved spati

• br Experimental section br Acknowledgements This work was fu

  2025-03-01

  

  Experimental section Acknowledgements This work was funded by the Italian Association for Cancer Research (AIRC IG18590 to A.A.), by “Fondi di Ateneo-University of Pisa” years 2009 and 2010 (E. N., S. N., E. O., and A. R.) and partially by the Unipi project P.R.A.2016_27 (E. N., E.O. and A. R.

• On the other hand there was no difference

  2025-03-01

  

  On the other hand, there was no difference in effectiveness performing ALK by FISH with regard to the sample site. When it was extracted from the primary tumor, we obtained 27.4% of not-evaluable specimens. Similar percentages were found for node (26.7%) and CRT0044876 (31.3%) samples (p = 0.903).

• AdipoRon acts on the anti diabetic effects of

  2025-03-01

  

  AdipoRon acts on the anti-diabetic effects of adiponectin, exhibiting its effect through the activation of AMPK and PPARα pathways via AdipoR1 and AdipoR2, respectively [23]. AdipoR activation is a promising treatment for diabetes, nonalcoholic fatty liver disease, and cardiovascular disease, demons

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